Flush is great for the tougher rooms and also have the ability to kill Dingle & Dangle instantly. Items that give any sort of brief invincibility like the Chariot card synergize well with E Coli allowing you to turn enemies into poop without worrying about the contact damage. Number One gives you a very good fire rate but limits your range quite significantly so one aim will be to pick up any boss items that extend range (Lazy Worm and Whip Worm are also great trinkets that extend your range with good effect) and pills can be a great resource if Range Up pills are in your run's rotation. E Coli and Flush both turn all regular enemies into poop which while holding Petrified Poop have a higher chance of dropping coins when broken open. E Coli and Flush both work well together with Petrified Poop. While the items may not seem too great, they can provide some useful combinations. Starting Items - Number One, E Coli, Butt Bombs, Flush, Petrified PoopĪ reasonably easy challenge, High Brow will see you make your way to and defeat Mom using items themed around toilet humor.As you only have to reach Mom, the challenge shouldn't be too difficult. Devil Deals can be potentially more dangerous than normal unless you are confident in your HP status. As for Curse of the Unknown, remember that you start with 3 HP as Isaac and simply try to keep track of any hits or heals you get as you proceed through the floor. If you want to make the Curse of Darkness less of an issue you can turn up the games gamma setting in options. The second issue you have is trying to keep track of your HP as Curse of the Unknown will stop you from being able to see how much HP you have left at any time.
The difficulty of the challenge comes with the screen being permanently darkened due to the Curse of Darkness being in effect. Your goal is to make it to Depths II (or its equivalent) and defeat Mom. Pitch Black is the first challenge and as such is not too difficult. Challenge Parameters - Permanent Curse of Darkness and Curse of the Unknown.Completing all challenges (both base game and DLC) are required to later unlock Real Platinum God and 1001%.
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